A Korean exosome pore ampoule from Medicube — 2000ppm of exosomes (Lactobacillus Extracellular Vesicles) paired with marine sponge spicules that create micro-channels in the skin to drive actives 242% deeper than standard absorption. Lightweight, non-sticky texture that penetrates through ten layers of skin.  ⚠️ A tingling, redness, or heat sensation is a normal reaction to the spicule formula — this is expected. Fragrance-free. 30ml.

• Exosomes 2000ppm — Pore Tightening —at 2000ppm, Lactobacillus Extracellular Vesicles act as cellular messengers that deliver active compounds directly to skin cells to support renewal, improve elasticity, and visibly tighten pores.
• Hydrolyzed Sponge (Marine Spicules) — 242% Deeper Absorption — fine needle-like silica spicules derived from marine sponge that create temporary micro-channels in the skin surface when massaged in. These channels allow the exosomes and actives to penetrate far deeper than the skin's surface barrier would otherwise allow — the reason absorption is enhanced by 242% and why you feel a tingling sensation during use.
• Niacinamide + BHA + PHA — Brighten + Clear + Exfoliate — Niacinamide evens skin tone and controls sebum. Betaine Salicylate is a gentler BHA that dissolves pore congestion. PHA provides gentle surface exfoliation with humectancy — together they clear and refine pores while the exosomes work on cell-level regeneration.
• Anti-Sebum P Complex — Sebum Control + Pore Minimize — Campsis Grandiflora + Pueraria Lobata + Pine Leaf + Evening Primrose + Ulmus Root. The same patented botanical complex found across multiple Medicube products — regulates sebum at the skin level to prevent pores from refilling.
• Adenosine + Panthenol + Glycerin — Firm + Soothe + Hydrate — Adenosine is Korean FDA-approved for wrinkle improvement. Panthenol soothes and supports barrier recovery after the spicule micro-channeling. Glycerin binds moisture to keep skin comfortable throughout use.

How to use

• BEGINNER: If you are not familiar with skincare products containing spicules, we do not recommend using them with our AGE-R devices.
  Step 1. After cleansing, prepare your skin with Meicube's Zero Pore Pads (or other hydrating toners).
  Step 2. Apply the Zero One Day Exosome Shot to the desired area (e.g., areas with uneven texture, enlarged pores, etc.) and gently rub and press to aid absorption.
  Step 3. Finish with Medicube's Collagen Jelly Cream (or your daily water-based moisturizer).
• STANDARD: Step 1. After cleansing, apply the Zero One Day Exosome Shot to your entire face, avoiding the area near your eyes and lips. For the best results, we recommend using the Exosome Shot as the first step in your skincare routine.
  Step 2. Gently rub and press with your hands to ensure that the needle-like formula is absorbed deep into your skin.
  Step 3. Finish with Medicube’s Collagen Jelly Cream (or your daily water-based moisturizer).

Usage Notes :Avoid applying near the eyes and lips.
For sensitive and delicate skin, we recommend conducting a patch test before use.
To achieve optimal efficacy, please familiarize yourself with the instructions for use.
You may experience a tingling, redness, itching, and heat sensation which may last for some time, but rest assured that this is a natural reaction to the Exosome Shot.